Supporting people with Cri du Chat Syndrome and their families

About Cri du Chat Syndrome

This section is a basic introduction to Cri du Chat Syndrome. It lists common symptoms, therapies, and other useful information.

If you need answers to your detailed medical or other clinical questions, you can contact our Clinical Advisory Group.

Cri du Chat Syndrome is caused by a missing section of the short arm of the fifth chromosome (5p-, in medical terms).

Around 85% of the time it is random, but in around 15% of cases it's inherited from a parent who may have the missing part, but not in the right place. This is called a translocation. That's why, as a parent of a child with CdCS, it's sensible to get your own chromosomes tested if you are considering having more children.

The effects of the syndrome vary a lot, depending on how much of the chromosome is deleted. It's important to note that not all the symptoms and treatments listed here will be relevant to all children (or adults) with CdCS.

Click the links in the sidebar for more information on the various topics.

Download You can download the information in this section as a PDF, which you can print and give to your GP or other professionals.
Download You can also download our older handbook for parents and professionals from 2003, written with medical researchers.
Information for Professionals

Cri du Chat Syndrome is an autosomal deletion syndrome caused by a partial deletion of chromosome 5p and is characterized by a distinctive, high-pitched, catlike cry in infancy with growth failure, microcephaly, facial abnormalities, and profound intellectual disability throughout life.

More general information can be found on the following websites: